Zhōu Zhīgàn 周之幹 (hào Shènzhāi 慎齋, mid-to-late Míng, conventional lifedate bracket c. 1508 – c. 1586 in modern Chinese-medicine reference works, undatable with precision), physician of DōngWú 東吳 (the Sūzhōu / Tàicāng region). Zhōu was a clinician of considerable mid-Míng reputation whose lineage was carried forward by his disciples into the early Qīng; he was particularly known for an idiosyncratic Shānghán-traditionalist clinical doctrine that the mid-Qīng editor GōuWú būrén 球 (球) framed as the true heir of Zhāng Zhòngjǐng against the four JīnYuán masters (see KR3er004 Zhōu Shènzhāi yíshū). Zhōu’s own publications during his lifetime are uncertain; his clinical doctrine survives principally through the Yíshū compilation transmitted in his disciples’ notebooks and brought to print in the mid-Qīng (1774 edition of Zhào Shùyuán 趙樹元). 張璐 Zhāng Lù’s Zhāngshì yītōng 張氏醫通 (1695, KR3ek020) cites Zhōu’s doctrine. No CBDB record; the conventional lifedate bracket is followed here.